4. (intr) (of a person or part of the body) to shed skin in flakes or (of skin) to be shed in flakes, esp as a result of sunburn. 5. (Croquet) croquet to put (another player's ball) through a hoop or hoops. 6. keep one's eyes peeled keep one's eyes skinned to watch vigilantly. slough off. 1. Literally, to shed, peel, or scrape off an outer layer of something. In this usage, a noun can be used between or after "slough" and "off.". It can be pretty gross to watch a lizard slough off its skin, leaving behind a weird, hollow version of itself. Define slough off. slough off synonyms, slough off pronunciation, slough off translation, English dictionary definition of slough off. also slew n. 1. A depression or hollow, usually filled with deep mud or mire. 2. also slue A swamp, marsh, bog, or pond, especially as part of a bayou.
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